Safety and efficacy of Reteplase IV Injection-recombinant plasminogen activator in management of ST elevated myocardial infarction (STEMI)
نویسندگان
چکیده
منابع مشابه
Post-Reteplase Evaluation of Clinical Safety & Efficacy in Indian Patients (Precise-In Study).
BACKGROUND ST elevated myocardial infarction is a serious and life-threatening condition. In patients suitable for thrombolytic treatment, time is critical and reperfusion should be initiated as soon as possible. Reteplase is commonly used in the management of ST elevated myocardial infarction. OBJECTIVE To assess the safety and efficacy of intravenous Retelex (Reteplase) injection in managem...
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BACKGROUND This study investigated the efficacy and the safety of the upstream glycoprotein (Gp) IIb/IIIa inhibitor (clotinab; ISU ABXIS, Seoul, Republic of Korea) under 600-mg clopidogrel pretreatment compared with provisional use in ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS A total of 786 STEMI patients were randomized to upstream use in the emergency room (ER) (n = 39...
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The effects of simultaneous intravenous infusions of 12 mg recombinant tissue-type plasminogen activator (rt-PA) over 30 minutes and 48 mg single-chain urokinase-type plasminogen activator (scuPA) over 40 minutes were studied in 38 patients with acute myocardial infarction. Coronary arterial patency was assessed angiographically 60 minutes and 90 minutes after initiation of treatment. Patency w...
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BACKGROUND No/slow reflow gives rise to serious complications in STEMI patients undergoing PCI, and can lead to worse outcomes. Several measures are used to prevent no/slow reflow, including thrombus removal processes and intensive use of anticoagulant agents. Our study was designed to evaluate the efficacy and safety of thrombectomy and intracoronary administration of GPIIb/IIIa inhibitors in ...
متن کاملexpression of the recombinant plasminogen activator (reteplase) by a non-lytic insect cell expression system
reteplase is a potent thrombolytic agent which is widely used in the management of acute myocardial infarction and stroke. it belongs to the third generation of the thrombolytic drugs and has been derived from native human tissue plasminogen activator by removing three domains of it and keeping the kringle 2 and serine protease domains. however, the high cost of this drug, has limited the appli...
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ژورنال
عنوان ژورنال: Indian Heart Journal
سال: 2014
ISSN: 0019-4832
DOI: 10.1016/j.ihj.2014.10.004